Dwayne Johnson plays Primatologist Davis Okoye, a man who keeps people at bay and prefer the company of animals instead. He shares a special bond with George, an intelligent silverback gorilla who has been in his care since birth. A rogue genetic experiment gone awry mutates this gentle ape into a raging creature of enormous size.
Other similarly altered-animals-turned-alpha predators tear across North America and destroy everything in their path, and it’s up to Okoye and a discredited genetic engineer to secure an antidote and to save the fearsome creature who was once his friend.
